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时间: 03-24 18:22 主题：无标题

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时间: 03-24 18:20 主题：LKLTN7

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时间: 03-24 18:17 主题：cryptocurrency market t479b

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时间: 03-24 18:16 主题：YqTroj

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时间: 03-24 18:12 主题：ZI81M7

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时间: 03-24 18:08 主题：o01NIg

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时间: 03-24 18:05 主题：无标题

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时间: 03-24 18:04 主题：EeChnT

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时间: 03-24 18:02 主题：无标题

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F Comparability of the MD-（ATPγS） atomic model to the cryo-EM map to level out the quality of match.
EM map and atomic model are colored based on key proven in （e）. The structural features of Cdc7 and Dbf4 are indicated and a close-up view of the active web site is proven. H Overview of the nucleotide occupancy and kind in each Mcm subunit throughout the MD-（ATPγS） complex.
In the G1 section of the cell cycle the helicase complex is loaded by ORC Cdc6 and Cdt1 onto the origin DNA. In this multi-step response two MCM2-7 hexamers are joined together to kind a head-to-head double-hexamer the place each hexamers become related through their N-terminal interfaces and encircle double-stranded DNA （dsDNA）2223.

This helicase advanced is initially inactive until DDK dependent phosphorylation of the MCM2-7 double hexamer （DH） through the G1-S transition overcomes the autoinhibitory exercise of the Mcm4 N-terminal tail132425.
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